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4.3.1 Oxidative stress induction CS generates excessive ROS, including superoxide anion, hydrogen peroxide, and hydroxyl radicals (135, 163)

As with almost all supplements, there have been reported side effects associated with taking larger amounts of creatine

A: Outcomes will vary between patients

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Notably, methodological developments we have emphasized include transfer learning of pretrained models from large cohorts, multimodal models fusing imaging information with clinical and/or genomics, explainability techniques for the interpretation of models-e.g., saliency maps, Grad-CAM-and federated learning methods to address privacy and generalization issues across institutions