GLP-1 success really looks the same as any other success as far as losing sufficient weight, says certified obesity medicine and bariatric surgeon Corrigan McBride, MD
Research has documented effects on approximately 4,000 genes, with 59% being upregulated (turned up) and 41% being downregulated (turned down)
Human studies mainly used short-term intravenous DSIP injections under controlled research conditions, typically at 25 nmol/kg, but these studies were small, short-duration, and not designed to establish long-term safety or optimal dosing
These include garlic, onions and the cruciferous vegetables such as broccoli, kale, collards, cabbage, cauliflower and watercress
Among the most promising candidates, supported by phase 1 and 2 clinical trials, is cagrilintide, a long-acting amylin and calcitonin receptor agonist