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This has been evaluated in the STEP-HFpEF (people with obesity and HFpEF without diabetes) and STEP-HFpEF DM (people with obesity and HFpEF with T2D) trials 44
Growth hormone peptides (CJC-1295, ipamorelin, sermorelin) are particularly relevant for this population because endogenous GH production declines approximately 14% per decade after age 30
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In one study of 208 patients, 45 experienced 88 fractures, with Standardized Incidence Ratios (SIRs) of 2.9 in females and 3.4 in males
The Caveat: BPC-157 is not a weight-loss compound
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