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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

Reviewing the historical literature also reveals that the introduction of bacteriostatic water for multi-dose injectable preparations dramatically reduced contamination incidents in hospital and research settings in the mid-20th century

Convenience factors Oral administration wins decisively on convenience

This makes Bacteriostatic Water particularly suitable for research environments where multiple doses or solutions must be prepared under sterile conditions