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Consistently, overexpression of hHPN WT in hepsin / mice resulted in a significant increase in APAP tolerance, with survival rates exceeding 80% even after 80 h (Fig

In addition, GBM cells have been shown to activate serine synthesis and one-carbon metabolism to survive glutamine deprivation

Comparison of therapeutic effects of garlic and d-Penicillamine in patients with chronic occupational lead poisoning

L-Buthionine sulfoximine (BSO) is a specific -glutamylcysteine synthetase inhibitor that blocks the rate-limiting step of glutathionine (GSH) biosynthesis and in doing so depletes the intracellular GSH pool in both cultured cells and in whole animals [10]

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