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Phase 2 body composition data from the Lancet Diabetes and Endocrinology substudy showed retatrutide achieving fat mass reductions of 15.2% at the 4mg dose, 26.1% at 8mg, and 23.2% at 12mg, while the proportion of lean mass loss relative to total weight loss remained comparable to other GLP-1 compounds
TRIUMPH-1, -2, and -3 run for 80 weeks (16 weeks escalation + 64 weeks maintenance)
liraglutide (28.9 vs
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Determination of the relative amount of migrated DNA provided a simple way to measure the number of SSBs in case of alkaline Comet assay and DSBs in case of neutral Comet assay (Olive and Banth, Two slides were used for each experimental point, and a number of cells 200 were randomly captured for each sample
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