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High-dose semaglutide and tirzepatide have produced even greater results in non-diabetic populations, often achieving a 10-15% reduction in baseline body weight
Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells
Moreover, as ENaC has been identified in type I cells and this is thought to be the main receptor for the detection of low NaCl-salts, these cells may transduce salty [46]
Rising prevalence of obesity 3.3.1.2
Compared with groups A1, 2 and 3, there was a significant decrease ( P 0.05)
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