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In the liver, glutathione binds with toxins to help move them out of the body

R Clinical implications of slow acetylation: Increased risk of isoniazid-induced hepatotoxicity and peripheral neuropathy (tuberculosis treatment) R Increased risk of sulfonamide hypersensitivity reactions R Increased risk of aromatic amine-related bladder cancer in occupational exposure settings (dye workers, rubber industry) R Drug-induced lupus from hydralazine and procainamide occurs almost exclusively in slow acetylators R Altered caffeine metabolism (slow acetylators clear caffeine more slowly via the NAT2 pathway) R NAT1 polymorphisms are less well characterized but the slow allele NAT1*14 has been associated with increased risk of cancers from dietary aromatic amines

But of more concern is really that it can cause receptor desensitization, maybe even turn off the whole receptor pathway

Ipamorelin stimulates GH release in discrete, pulsatile bursts similar to endogenous GH secretion physiology

10.1053/j.gastro.2022.01.023 25 LambC