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NPT1 ( SLC17A1 ) The SLC17A1 , a membrane protein, is the first member of the SLC17 phosphate transporter family (Zhang et al., 2018)
It mainly stimulates insulin secretion and inhibits the release of glucagon by binding to receptors on pancreatic beta cells, thus helping to lower blood glucose levels
What It Actually Is
Inhibitors for these abovementioned protein targets have entered clinical trials ( Figure 1 )
The increased activity can be attributed to improved binding affinity to pituitary receptors, enhanced resistance to inactivation, and a conformational change induced by type II bending
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