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26 Subjects were administered 0.75 mg of liraglutide as a single dose, and evaluated after a 72-hour period to determine if hepatic impairment influenced liraglutides pharmacokinetic and safety profile

HepaRG cells were exposed to APAP (10 mM) for 6 hours, then washed to remove cell debris and new culture medium was added for an additional 6 hours

My takeaway The oral obesity race is rapidly evolving from who loses the most weight to who patients can stay on the longest. As multiple oral GLP-1 therapies converge around similar efficacy, long-term tolerability, convenience, and real-world persistence are becoming the key commercial battleground