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2DF, dose-dependent treatment with SP reduced the proportions of M1-like macrophages as well as increased the proportions of anti-inflammatory M2-like macrophages (mannose receptor CD206 as the phenotypic marker of M2-like macrophages), suggesting that SP inhibited the polarization of proinflammatory M1-like macrophages and promoted the differentiation of anti-inflammatory M2-like macrophages
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MnO2 also combines with GSH to form Mn2 +, which facilitates Magnetic Resonance Imaging (MRI-guided) CDT [77]
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