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The accumulation of LCACs promotes mitochondrial failure by producing ROS [291], which block mitochondrial -oxidation by inhibiting redox-sensitive Slc25a20

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Moreover, insulin resistance of the adipose tissue, associated with overweight/obesity, contributes to the flux of FFA from adipose tissue to the liver through unrestricted lipolysis (19)

The ACM concluded that the current evidence may support the signal for semaglutide, but not dulaglutide or tirzepatide