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Combination therapy: When combined with semaglutide 2.4 mg (CagriSema), phase 3 REDEFINE trials showed approximately 20% weight loss at 68 weeks, exceeding results with either agent alone [5] [12]

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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization

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