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7E and Fig.S3, SLC25A39 was mainly expressed in epithelial cells (colon adenocarcinoma cells), macrophage and tissue-stem cells, which suggested that SLC25A39 might also be involved in regulation of the cellular behavior of macrophage and tissue-stem cells
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main purpose Receptor binding and activation of signaling pathways IGF-1 LR3 activates two main downstream signaling pathways by binding to the IGF-1 receptor (IGF-1R): PI3K/Akt pathway: promotes cell survival, glucose metabolism, and protein synthesis
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