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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11
Firefighters are exposed to toxic smoke, chemicals, and environmental pollutants, which can lead to respiratory damage, oxidative stress, and long-term health risks
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