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Limitations and Remaining Questions While semaglutide has shown significant benefits in reducing joint pain among patients with obesity, several important limitations remain: Studies often lack post-treatment follow-up, making it unclear how durable these pain and weight outcomes are once medication is stopped

Although it has the same active ingredient as Wegovy (semaglutide), Ozempic is primarily approved to control blood sugar levels in adults with type 2 diabetes

Gastrointestinal side effects remain common, titration strategies require patience, and certain patientsespecially those with medullary thyroid carcinoma, severe gastroparesis, or history of pancreatitismay not qualify for therapy

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