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The proinflammatory RAGE/NF-kappaB pathway is involved in neuronal damage and reactive gliosis in a model of sleep apnea by intermittent hypoxia

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Peer review Peer review information Nature Reviews Drug Discovery thanks Timo Mller and the other anonymous reviewer/s for their contribution to the peer review of this manuscript

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Rather than reflecting a simple imbalance between energy intake and expenditure, obesity represents an actively defended physiological state in which compensatory mechanisms promote weight regain following weight loss attempts ( Among these strategies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as the most effective anti-obesity pharmacotherapies to date