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Through systematic analysis of clinical trials, meta-analyses, and emerging evidence from landmark studies like SELECT, this paper evaluates whether GLP-1 agonists represent a transformative breakthrough or an overhyped intervention with significant limitations

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The ACHIEVE-3 study enrolled 1,698 patients across the United States, Argentina, China, Japan, Mexico, and Puerto Rico to receive either 12 mg or 36 mg of orforglipron or 7 mg or 14 mg of oral semaglutide