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1/Smad2/3 axis, a key pathway in fibrosis and epithelial-mesenchymal transition, thus reducing tissue fibrosis and promoting regenerative over fibrotic repair 4

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GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction