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The characteristic features of the severe forms of 3MCC deficiency include difficulty feeding, recurrent episodes of vomiting and diarrhea, lethargy, and hypotonia

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Hematological parameters were reported using standard units (10/L for WBCs, 10/L for RBCs, g/dL for hemoglobin, and 10/L for platelets), and reference ranges for mice were provided by the analyzer manufacturer

eccCDSs variants carried on eccDNA can diverge from their chromosomal templates without compromising core genome integrity, allowing even individual cells to explore new allelic or regulatory states