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Our findings indicate that AMPK activation mediates the effects of GLP-1RAs on AD, highlighting the therapeutic potential of GLP-1RAs for the treatment of AD
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When a biopsy is performed, partial sampling should be avoided (with the exception of a large lesion in a cosmetically sensitive area)
Figure 7 4.1 Hepatocyte-targeted interventions Hepatocytes serve as the central hub of lipid accumulation and metabolic dysregulation in MASH ( de novo lipogenesis (DNL) through modulation of ACLY, ACC1/2, FASN, or DGAT2 effectively reduce hepatic triglyceride content, oxidative stress, and downstream inflammatory signaling ( 4.2 Kupffer cell-targeted interventions Kupffer cells orchestrate hepatic inflammation and contribute to systemic insulin resistance ( 4.3 HSC-targeted interventions HSCs are the principal fibrogenic cells driving ECM deposition and fibrosis in MASH ( 4.4 Pancreatic cells-targeted interventions Pancreatic -cells are essential for maintaining glucose homeostasis, and their dysfunction or loss is a key contributor to T2DM ( 4.5 Combination and multi-target strategies Single-target interventions frequently yield partial therapeutic effects, whereas combinatorial approaches targeting hepatocytes, Kupffer cells, and HSCs demonstrate superior efficacy
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