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typically serum B12 below the reference range with clinical symptoms
For comparison, see how the GLP-1 incretin axis works there are mechanistic similarities (appetite suppression, gastric emptying delay) between amylin and GLP-1, but they operate through distinct receptor systems
The peptide still distributes systemically from a local injection, so you get both targeted and whole-body effects
There's also substantial evidence connecting B12 status to mood regulation, with deficiency associated with increased risk of depression and anxiety
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