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Tip: The thigh (outer upper leg) is a good alternative site and easy to reach when injecting alone

Hypoglycemia is also a potential risk with both drugs, especially in people taking other medications for diabetes

Site rotation across these regions on a weekly basis is standard practice for all once-weekly subcutaneous peptide administrations, and is particularly important during extended retatrutide dosing studies where repeated injection at a single site can cause localized lipodystrophy or reduced absorption efficiency

All GLP-1 analogs significantly or slightly reduced plasma AST, ALT, TG, TC, insulin, and HOMA-IR levels (Fig

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