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2015;1(2):e388-e391

Rothe and J

Understanding the relationship between these compounds is essential for optimizing your treatment strategy

Lipid peroxidation preferentially accumulates at lysosomal membranes and precedes lysosome rupture, transcription factor EB (TFEB) activation, and cathepsin-dependent plasma membrane breakdown, thereby positioning lysosomal stress at the center of population-scale death amplification