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It could be speculated that this increased discontinuation rate vs all comparators, including GLP-1 RAs, may be possibly attributed to the severity of gastrointestinal adverse events experienced with tirzepatide 15 mg, considering that the incidence of gastrointestinal adverse events was similar between tirzepatide and GLP-1 RAs

Some studies point to possible underreporting because symptoms don't always follow typical patterns

GLP-1 suppresses glucagon secretion in human pancreatic alpha cells

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