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Effect of food consumption on the pharmacokinetics, safety, and tolerability of once-daily orally administered orforglipron (LY3502970), a non-peptide GLP-1 receptor agonist
N Engl J Med 2025;392:2089-2099
Confidence rebuilds
That story seemed intuitively obvious, and the STEP 9 trial published in NEJM supported it 407 obese patients with knee OA experienced significant pain reduction and improved function with semaglutide 2.4 mg weekly versus placebo
This suggestion was wrong since drugs that increase ACE2 expressions, like ibuprofen and angiotensin receptor blockers (ARBs), are protective rather than harmful when used in Covid-19 (Kelleni 2020
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