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Storing a peptide solution at 4 degrees Celsius instead of room temperature slows this hydrolysis substantially, because the reaction rate roughly halves for every 10-degree Celsius drop in temperature (Arrhenius kinetics)
These benefits are thought to arise from both weight-dependent and weight-independent mechanisms, including anti-inflammatory effects [3537]
The molecule makes three changes to the native hormone fragment: a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, inversion to D-phenylalanine at position 7, and substitution of norleucine for the oxidation-prone methionine at position 4
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