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Notably, Zepbound, approved in late 2023, has shown the fastest growth, with sales projected to more than double from last year, reaching $11.3 billion

This result indicates that chronic treatment with GLP-1R agonists could lead to proliferation/chronic activation of PSCs, with serious side effects

Cardiovascular risk : If you have established cardiovascular disease or high cardiovascular risk, your clinician may favour agents with proven cardiovascular benefits in outcome trials, such as semaglutide, liraglutide, or dulaglutide

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