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Two additional trials, CREDENCE (Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy) (canagliflozin) and DAPA-HF (Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction) (dapagliflozin), evaluated alternative primary outcomes of renal events and HF events in patients with CKD stage 2/3 and chronic HF, respectively, and analyzed 3P-MACE as a secondary endpoint

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