Studies have shown that in patients with active juvenile dermatomyositis, a reduction in peripheral circulating CD8 + T cells may be linked to specific muscle injury phenotypes (206)
However, the studys authors noted that long-term impacts could exist and that more research is likely needed
Gradual dose escalation can significantly mitigate the frequency and severity of symptoms such as nausea and diarrhea, as it allows patients to adapt to therapy over time (Rodriguez et al., 2025)
O., Subramaniapillai, M., Lovshin, J., & McIntyre, R
However, the supplementary in-trial analysis of all available scans demonstrated similar results, supporting the robustness of the conclusion for this endpoint