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Wen H, Yang HJ, An YJ, et al

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These data suggest a potential for long-term benefit of liraglutide treatment in many patients, as weight loss of 515% has been shown to improve obesity-related complications including diabetes and cardiovascular disease risk factors [5, 9, 59]

ERR agonism the primary driver ERR is highly expressed in energy-demanding tissues such as skeletal muscle, heart, brown adipose tissue, and liver

However, despite encouraging early laboratory findings, its clinical development was discontinued in 2007 after failing to demonstrate significant weight-loss efficacy in large-scale human trials