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Measures precursor ion mass with high accuracy Confirms molecular weight of GLP-1 peptide Detects mass shifts due to modifications Key Insight: High-resolution MS enables differentiation of closely related peptide species

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to dna damage by inhibiting mitochondrial glutamine metabolism

Carnitine, L- 30

doi: 10.1007/s12031-019-1257-9 214 Long-SmithCMManningSMcCleanPLCoakleyMFOHalloranDJHolscherCet al

LFD control slides are set to baseline of 1 to account for resident Kupffer cells (dark stained spots disperse equally between hepatocytes)