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While pharmacotherapy may delay surgery, it does not replace its role in adolescents with severe obesity and comorbidities

For young men specifically, the choice often involves weighing availability and regulatory status against efficacy potential

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Metabolic secondary outcomes included HbA1c, blood pressure (systolic and diastolic), HR, total cholesterol, triglycerides, hsCRP, HbA1c in participants with pre-existing pre-diabetes and T2D, blood pressure in participants with pre-existing hypertension and changes in T2D, and hypertension medication used in participants with T2D and hypertension, respectively

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