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Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

For confirmed deficiency or pernicious anaemia, NICE Clinical Knowledge Summaries recommend hydroxocobalamin 1mg intramuscularly, with frequency determined by the underlying cause and neurological involvement

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Behavioral assessments showed treated animals became notably more active and responsive to environmental stimuli, exhibiting exploratory behaviors typically absent in aged subjects