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Slowly titrating the dose over months allows the body to clear the toxic burden without triggering a massive immune flare or severe Herxheimer reaction

They designed a 16-week prospective randomized open-label study with 30 men, with BMI 41.2 8.4 kg/m2 and aged 46.5 10.9 years

once daily, to improve convenience and adherence

Moreover, it was established that the tested doses (30 or 60 g/kg) were well-tolerated [3]

One possible hypothesis leading to this observation could be related to the increasing concentration of TG in the remaining VLDL and rising of TG antiport with HDL-C at the same time.[] One study showed a contrasting result by reporting the effect of carnitine on the HDL-C level