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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted
Among these, the use of cell-penetrating peptides (CPPs), short protein transduction domains (PTDs) that facilitate the intracellular transport of various bioactive molecules, has become an area of extensive research in the intranasal delivery of peptides and proteins either to systemic or to brain compartments
While the efficacy of herbal GLP-1 patches is doubtful and GLP-1 drug patches are still under trial, this delivery system through skin is said to have some potential benefits like 6 : Note: The benefits mentioned above are only theoretical as there are no GLP-1 patches which are FDA approved
The projected timeline for remaining pivotal trials is early to mid-2026, with data publication expected shortly thereafter
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