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Gallstones were more common with semaglutide (about 2.6% vs 1.2% with placebo) in the STEP trials, consistent with rapid weight loss in general

During the Digestive Disease Week Conference in 2024 , scientists claimed that GLP-1 and its side effects could eventually lead to gastroparesis, which is defined as the slowing down of your stomachs digestion

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Contrave : This non-GLP-1 medication works on appetite and reward pathways and has been shown to help quiet food noise

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