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Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH

Chlorantraniliprole, a common diamide insecticide, also pushes S4 away from the other pVSD helices, although to a smaller extent

The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis