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CAN is associated with a higher incidence of cardiovascular events and mortality among diabetes patients
IGF-1 promotes the function of immunosuppressive FOXP3 + regulatory T-cells (Tregs) and enhances T-cell secretion of cytokines including IL10, required for macrophage polarization to the pro-tumorigenic, immunosuppressive M2 phenotype 6,7,8
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Third, the typical metabolic defects of patients with T2DM such as impaired insulin secretion and insulin resistance can be mimicked in animals by a progressive loss of -cells [14]
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