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The data is consistent across trials: tirzepatide 15mg produces ~6 percentage points more weight loss than semaglutide 2.4mg, and even tirzepatide's lowest dose (5mg) matches semaglutide's maximum

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These neurological changes happen quickly because semaglutide immediately interacts with GLP-1 receptors in the brain that regulate hunger and satiety

Some drugs and other substances can interact with Contrave, including alcohol, MAOIs (like isocarboxazid, linezolid, phenelzine, selegiline, or tranylcypromine), drugs that increase dopamine levels in your system (like levodopa and amantadine), drugs that affect the central nervous system (like antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medication), drugs for depression or anxiety, antipsychotics, theophylline, systemic corticosteroids, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder (ADHD), medicine for seizures or barbiturates, muscle relaxants, anesthetics, including some dental anesthetics, dextromethorphan, diarrhea medication (such as diphenoxylate), disulfiram, opioid pain or cough relievers (such as codeine and hydrocodone), thioridazine