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The crystal structure of IRAP in complex with 44 reveals that the enzyme undergoes structural reconfiguration that allows the accommodation of bulky side chains of the inhibitor
In conclusion, iron metabolism is closely related to the bone microenvironment, and ferroptosis may play an important role in the pathogenesis of osteoporosis
Beharier found that spontaneous preterm birth associated with placental dysfunction showed placental ferroptosis, accumulation of lipid peroxides in the placenta, and increased sensitivity of iPLA2-deficient trophoblast cells to ferroptosis [43]
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Research Applications & Contexts Cagrilintide is being investigated across multiple research contexts focused on metabolic regulation, weight management, and glucose homeostasis
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