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Significant creatinine elevation As discussed, a small early increase in creatinine and corresponding eGFR dip is expected

The importance of timely intervention becomes clear when considering that approximately one-third of patients lose less than 0.5% body weight weekly during the first month of intensive behavioral treatment

Starting dose is 0.25 mg weekly for at least the first month

It serves critical roles in cellular redox reactions for energy metabolism and acts as an essential substrate for key signaling enzymes regulating DNA repair, gene expression, and cell signaling