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196 showed that cystine levels are lower in tumour interstitial fluid in murine pancreatic adenocarcinomas (PDACs) than in plasma, which may indicate that cancer cells actively uptake cysteine

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In the past, therapeutic agents for ovarian cancer have been limited, and researchers have usually described the underlying mechanism and explored therapeutic strategies for overcoming resistance based on the drug classification

The cytosolic enzyme is encoded by the SHMT1 gene on chromosome 17 and the mitochondrial enzyme is encoded by the SHMT2 gene on chromosome 12

Dominguini, D