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digestive upset in general is common, and it's something that can be miserable but is at least not immensely dangerous
Dehydration can impair glucose metabolism studies have demonstrated that even mild dehydration may be associated with elevated blood glucose levels, though this occurs through mechanisms unrelated to incretin hormones
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50,51 DDIs with Narrow Therapeutic Index Drugs Other clinical studies on DDIs have investigated the delayed gastric emptying effect of GLP-1 RA on the pharmacokinetics of drugs with narrow therapeutic index (Table 5)
The cardiovascular data is sobering and deserves serious consideration
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