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Examples include rats for short-term vascularization and pigs for volume and mechanical match to human soft tissue

doi: 10.3389/fimmu.2025.1525623 Received 11 November 2024 Accepted 19 February 2025 Published 11 March 2025 Volume 16 - 2025 Edited by James Cheng-Chung Wei, Chung Shan Medical University Hospital, Taiwan Reviewed by Venkateswarlu Kanamarlapudi, Swansea University Medical School, United Kingdom Ching-Hua Huang, Chung Shan Medical University Hospital, Taiwan Updates Copyright 2025 Sun, Hao, Liu and Gao

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This makes them ideal locations for a shot that needs to be injected just under the skin, as opposed to an intramuscular injection that needs to go past layers of skin and fat to get deep into a muscle