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5a,f and 7a, and Supplementary Fig
Black Box Warnings for Topical Cocaine: NOT FOR INJECTION OR OPTHALMIC USE Pharmacokinetics: A topical local anesthetic (its only FDA approved use) As a drug of abuse the HCl can be sniffed, taken orally or injected IV
Analytical reproducibility relies on consistent retention behaviour, spectral conformity and molecular mass confirmation
Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours
