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Results: The models explain why women of childbearing age have higher glutathione than men, and that this is caused by the balance of activation of glutamyl cysteine synthetase (GCL) and glutathione peroxidase (GPX) by estradiol

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Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals

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This enzyme is crucial in producing melanin the pigment responsible for skin color