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Genetic variants in NPC1L1 , regulating cholesterol absorption in the canalicular membrane and in the enterocyte in humans might also be involved in in cholesterol hypersecretion, although studies with the specific NPC1L1 inhibitor ezetimibe argue against this possibility [39,40,41,42,43,44] and need to be further investigated
Clinical studies have confirmed significant alterations in both the gut microbiota composition and BAs profiles in SZ patients (77), highlighting a potential correlation between BAs dysregulation and the disorder
Researchers should follow established protocols for reconstitution and sterile administration
The ex vivo synthesized sequences of FAPCAR were cloned into IVT template plasmid as the ORF region which also carried T7 promoter, modified 5 UTR, kozak sequence, 3 UTR, and a 110 nt-long poly (A) tail 59,60,61
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