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High doses (1,000+ mg/day) are often needed for minimal effects

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84 ACC inhibitors reduce hepatic steatosis in patients with MASLD, but they also increase serum triglycerides

Avoid taking high-dose B6 supplements without consulting your doctor: While the daily upper limit is set at 100 mg pyridoxine, there have been reported cases of pyridoxine-induced neuropathy in people taking 25 to 50 mg per day for longer than six months