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Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

Adverse effects of combination therapy included an increased risk of genital infections and diarrhea (Milder 2019)

BMJ 334 , 11591162 (2007)